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Among Nature Biotechnology's top news stories of 2023 is a profile of companies developing RNA editing for therapeutic applications, including Korro Bio, co-founded by MBL Senior Scientist Joshua Rosenthal. RNA editing "is rapidly gaining prominence as its transient and reversible changes promise a safer and more flexible option to reverse disease-causing mutations than DNA editing," the editors write.

Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashing GLP-1 agonist, with AI-hallucinated proteins a close second. These are followed by drugging options for RNA. The dark horses are virus-free gene therapies and a sweet protein.

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Source: Top Ten News Stories of 2023 | Nature Biotechnology